Islet Cell Signaling

UNIT of Cell Physiology and Nutrition

Islet Cell Signaling

Regulation of α, β and δ-Cells

Human Nutrition

 

Islet Cell Signaling

Islet Cell Signaling

 
Group leaders: ÁNGEL NADAL and PALOMA ALONSO-MAGDALENA

Endocrine Disruptors and Type-2 Diabetes  

We are interested in the role that endocrine disruptors, particularly Bisphenol-A, have in the etiology of Diabetes. We study how exposure to EDCs at different times during life affects insulin sensitivity and the function of the endocrine pancreas. We have interest in how endocrine disruptors exposure during pregnancy affects offspring glucose metabolism later in life.

17 β-Estradiol and Environmental Estrogen Actions on the Endocrine Pancreas.

We work to understand the role that estrogen receptors ERα, ERβ and GPER1 have in the physiology of the islet of Langerhans. This will give light on how estrogens influence the plasticity of the endocrine pancreas during the adaptation to pregnancy and obesity. In addition, this will help us to better understand the role of estrogen receptors in low dose effects of endocrine disruptors with estrogenic activity and how they affect insulin biosynthesis and release.

Selected publications:

  • Alonso-Magdalena P, Ropero AB, Garcia-Arevalo M, Soriano S, Quesada I, Muhammed SJ, Salehi A, Gustafsson JA, Nadal A. (2013) Antidiabetic actions of an ERβ selective agonist. Diabetes. 62:2015-2025.
  • García-Arevalo M, Alonso-Magdalena P, Rebelo Dos Santos J, Quesada I, Carneiro EM, Nadal A. (2014) Exposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice. Plos One. 9: e100214.
  • Alonso-Magdalena P, García-Arévalo M, Quesada I, Nadal A. (2015) Bisphenol-A Treatment During Pregnancy in Mice: A New Window of Susceptibility for the Development of Diabetes in Mothers Later in Life. Endocrinology. 156: 1659–1670.
  • García-Arévalo M, Alonso-Magdalena P, Servitja JM, Boronat T, Merin B, Villar S, Medina-Gómez G, Novials A, Quesada I, Nadal A. (2016) Maternal exposure to Bisphenol-A during pregnancy increases pancreatic β-cell growth during early life in male mice offspring. Endocrinology. 157:4158-4171.
  • Nadal A, Quesada I, Tudurí E, Nogueiras R, Alonso-Magdalena P. (2017) Endocrine-disrupting chemicals and the regulation of energy balance. Nat Rev Endocrinol. 13: 536-546.
  • Villar-Pazos S, Martinez-Pinna J, Castellano-Muñoz M, Alonso-Magdalena P, Marroqui L, Quesada I, Gustafsson JA, Nadal A.. (2017) Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells. Scientific Reports. 7(1):11770.