Publications

UNIT of Cell Physiology and Nutrition

Islet Cell Signaling

Regulation of a, ß and d-Cells

Human Nutrition

ARTICLES

Present-2003
  1. Soriano S, Gonzalez A, Marroqui L, Tuduri E, Vieira E, Amaral AG, Batista TM, Rafacho A, Boschero AC, Nadal A Carneiro EM, Quesada I. (2010) Reduced insulin secretion in protein malnourished mice is associated to multiple changes in the beta-cell stimulus-secretion coupling. Endocrinology. In press.
  2. Ropero AB, Soriano S, Tudurí E, Marroquí L, Tellez N, Gassner B, Juan-Picó P, Montanya E, Quesada I, Kuhn M, Nadal A. (2010) Islets of Langerhans from guanylyl ciclase-A KO mice have decreased beta cell mass and improved glucose-induced insulin secretion. Endocrinology. In press.
  3. Nadal A, Alonso-Magdalena P, Soriano S, Ripoll C, Fuentes E, Quesada I, Ropero AB. (2010) Roles of estrogen receptor alfa, estrogen receptor beta and G protein-coupled estrogen receptor in pancreatic beta-cells. Frontiers in Biosciences. In press.
  4. Soria B, Tuduri E, Gonzalez A, Hmadcha A, Martin F, Nadal A, Quesada I. (2010) Pancreatic islet cells: a model for calcium-dependent peptide release. HFSP Journal. 4: 52-60.
  5. Alonso-Magdalena P, Ropero AB, Soriano S, Quesada I, Nadal A. (2010) Bisphenol-A: a new diabetogenic factor?. Hormones. 9: 118-126.
  6. vom Saal FS, Akingbemi BT, Belcher SM, Crain DA, Crews D, Guidice LC, Hunt PA, Leranth C, Myers JP, Nadal A, Olea N, Padmanabhan V, Rosenfeld CS, Schneyer A, Schoenfelder G, Sonnenschein C, Soto AM, Stahlhut RW, Swan SH, Vandenberg LN, Wang HS, Watson CS, Welshons WV, Zoeller RT. (2010) Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research. Toxicological Sciences. 115: 612-613.
  7. Wendler A, Baldi E, Harvey BJ, Nadal A, Norman A, Wehling M. (2010) Position paper: Rapid responses to steroids: current status and future prospects. European Journal of Endocrinology. 162: 825-830.
  8. Alonso-Magdalena P, Vieira E, Soriano S, Menes L, Burks D, Quesada I, Nadal A. (2010) Bisphenol-A Exposure during Pregnancy Disrupts Glucose Homeostasis in Mothers and Adult Male Offspring. Environmental Health Perspectives. In press.
  9. da Silva PM, Zoppi CC, Filiputti E, Silveira LR, Quesada I, Boschero AC, Carneiro EM. (2010) Leucine supplementation enhances glutamate dehydrogenase expression and restores glucose-induced insulin secretion in protein-malnourished rats. Metabolism. 59: 911-913.
  10. Filiputti E, Rafacho A, Pereira de Araújo E, Silveira LR, Trevisan A, Batista TM, Curi R, Velloso LA, Quesada I, Boschero AC, Carneiro EM. (2010) Augmentation of insulin secretion by leucine supplementation in malnourished rats: Possible involvement of the PI3K/mTOR pathway. Metabolism. 59: 635-644.
  11. Rafacho A, Marroquí L,Taboga SR, Abrantes JLF, Silveira LR, Boschero AC, Carneiro EM, Bosqueiro JR, Nadal A, Quesada I. (2010) Glucocorticoids in Vivo Induce Both Insulin Hypersecretion and Enhanced Glucose Sensitivity of Stimulus-Secretion Coupling in Isolated Rat Islets. Endocrinology. 151: 85-95.
  12. Carneiro EM, Latorraca MQ, Araujo E, Beltrá M, Oliveras MJ, Navarro M, Berná G, Bedoya FJ, Velloso LA, Soria B, Martín F. (2009) Taurine supplementation modulates glucose homeostasis and islet function. Journal of Nutritional Biochemistry. 20: 503-511.
  13. Soriano S, Ropero AB, Alonso-Magdalena P, Ripoll C, Quesada I, Gassner B, Kuhn M, Gustafsson JA, Nadal A. (2009) Rapid Regulation of KATP Channel Activity by 17beta-Estradiol in Pancreatic beta-Cells Involves the Estrogen Receptor beta and the Atrial Natriuretic Peptide Receptor. Molecular Endocrinology. 23: 1973-1982.
  14. Nadal A, Alonso-Magdalena P, Soriano S, Ropero AB, Quesada I. (2009) The role of estrogens in the adaptation of islets to insulin resistance. Journal of Physiology. 587: 5031-5037.
  15. Piquer S, Casas S, Quesada I, Nadal A, Julia M, Novials A, Gomis R. (2009) Role of iduronate-2-sulfatase (IDS) in glucose stimulated insulin secretion by activation of exocytosis. American Journal of Physiology. Endocrinology & Metabolism. 297: E793-801.
  16. Sun J, Yao J, Huang S, Long X, Wang J and García-García E. (2009) Antioxidant activity of polyphenol and anthocyanin extracts from fruits of Kadsura coccinea (Lem.) A.C. Smith. Food Chemistry. 117: 276-281.
  17. Tuduri E, Marroquí L, Soriano S, Ropero AB, Batista TM, Piquer S, López-Boado MA, Carneiro EM, Gomis R, Nadal A, and Quesada I. (2009) Inhibitory effects of leptin on the pancreatic alpha-cell function. Diabetes. 58:1616-1624.
  18. Juan Pico P, Ropero AB, Tudurí E, Quesada I, Fuentes E, Bermudez-Silva FJ, Rodriguez de Fonseca F and Nadal A. (2009) Regulation of Glucose-induced [Ca2+]i signals by cannabinoid CB1 and CB2 receptors in pancreatic alpha and delta cells within intact islets of Langerhans. Obesity and Metabolism. 5: 20-28.
  19. Myers JP, vom Saal F, Akingbemi BT, Arizono K, Belcher S, Colborn T, Chahoud I, Crain DA, Farabolli F, Guillete Jr LJ, Hassold T, Ho S, Hunt PA, Iguchi T, Jobling S, Kanno J, Laufer H, Marcus M, McLachlan JA, Nadal A, Oelhmann J, Olea N, Palanza P, Parmigiani S, Rubin BS, Schoenfelder G, Sonneschein C, Soto AM, Talsness CE, Taylor JA, Venderberg LN, Vanderbergh JG, Vogel S, Watson CS, Welshons WV and Zoeller T. (2009) Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol-A. Environmental Health Perspectives 117. 309-315.
  20. Todorova M, Fuentes E, Soria B, Nadal A, Quesada I. (2009) Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway. Cellular Signalling 21. 523-528.
  21. Bermúdez-Silva FJ, Suarez-Pérez J, Nadal A and Rodríguez de Fonseca F. (2009) The role of pancreatic endocannabinoid system in glucose metabolism. Best Practice and Research Clinical Endocrinology and Metabolism 23. 87-102.
  22. Nadal A, Alonso-Magdalena P, Soriano S, Quesada I, Ropero AB. (2009) The pancreatic beta-cell as a target of estrogens and xenoestrogens: implications for blood glucose homeostasis and diabetes. Molecular and Cellular Endocrinology. 304: 63-68.
  23. Ropero AB, Juan-Picó P, Rafacho A, Fuentes E, Bermúdez-Silva FJ, Roche E, Quesada I, Rodríguez de Fonseca F, Nadal A. (2009) Rapid, non-genomic regulation of calcium signals and insulin secretion by PPARalpha ligands in mouse pancreatic islets of langerhans. Journal of Endocrinology. 200: 127-138.
  24. Quesada I, Tuduri E, Ripoll C, Nadal A. (2008) Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. Journal of Endocrinology. 199: 5–19.
  25. Fernández-Real JM, López-Bermejo A, Ropero AB, Piquer S, Nadal A, Bassols J, Casamitjana R, Gomis R, Arnaiz E, Pérez I, Ricart W. (2008) Salicylates increase insulin secretion in healthy obese subjects. Journal of Clinical Endocrinology and Metabolism. 93: 2523-2530.
  26. Ripoll C, Ropero AB, Alonso-Magdalena P, Quesada I, Fuentes E, Nadal A. (2008) Rapid Regulation of Pancreatic alpha- and beta- Cell Signalling Systems by Estrogens. Infectious Disorders - Drug Targets . 8: 61-64.
  27. Alonso-Magdalena P, Ropero AB , Carrera MP, Cederroth CR, Bathié M, Gauthier BR, Nef S, Stefani E, Nadal A. (2008) Pancreatic insulin content regulation by the estrogen receptor ERalpha. PLoS ONE 3(4): e2069. doi:10.1371/Journal.pone.0002069.
  28. Tudurí E, Filiputti E, Carneiro EM, Quesada I. (2008) Inhibition of Ca2+ signaling and glucagon secretion in mouse pancreatic alpha-cells by extracellular ATP and purinergic receptors. American Journal of Physiology. Endocrinology & Metabolism. 294: E952-E960.
  29. Ropero AB , Alonso-Magdalena P, Quesada I, Nadal A. (2008) The role of estrogen receptors in the control of energy and glucose homeostasis. Steroids . 73: 874-879.
  30. Bermúdez-Silva FJ, Suárez J, Baixeras E, Cobo N, Bautista D, Cuesta-Muñoz AL, Fuentes E, Juan-Pico P, Castro MJ, Milman G, Mechoulam R, Nadal A, Rodríguez de Fonseca F. (2008) Presence of functional cannabinoid receptors in human endocrine pancreas. Diabetologia . 51: 476-87.
  31. Todorova MG, Soria B, Quesada I. (2008) Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state. Journal of Cellular Physiology . 214: 354-362.
  32. Quesada I.*, Villalobos C.*, Núñez L., Chamero P., Alonso M.T., Nadal A., García-Sancho J.. (2008) Glucose induces synchronic mitochondrial calcium oscillations in β-cells within intact mouse pancreatic islets. Cell Calcium . 43: 39-47.
  33. Ropero AB , Alonso-Magdalena P, García-García E, Ripoll C, Fuentes E and Nadal A. (2008) Bisphenol-A disrupts the endocrine pancreas and blood glucose homeostasis. International Journal of Andrology . 31: 194-200.
  34. Bermudez-Silva FJ , Sánchez-Vera I, Suarez J, Serrano A, Fuentes E, Juan-Pico P, Nadal A and Rodríguez de Fonseca F. (2007) Role for cannabinoid CB2 receptors in glucose homeostasis in rats. European Journal of Pharmacology . 565:207-211.
  35. Wetherill YB, Akingbemi B, Kanno J, McLachlan JA, Nadal A, Sonnenschein C, Watson CS, Zoeller RT and Belcher SM . (2007) In Vitro Molecular Mechanisms of Bisphenol-A Action. Reproductive Toxicology . 24:178-198 .
  36. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, Farabollini F, Guillette LJ Jr, Hauser R, Heindel JJ, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Keri RA, Knudsen KE, Laufer H, LeBlanc GE, Marcus M, McLachlan JA, Myers JP, Nadal A, Newbold RR, Olea N, Prins GS, Richter CA, Rubin BS, Sonnenschein C, Soto AM, Talsness CE, Vandenbergh JG, Vandenberg LN, Walser-Kuntz DR, Watson CS, Welshons WV, Wetherill Y and Zoeller RT. (2007) Chapel Hill bisphenol-A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reproductive Toxicology . 24: 131-138.
  37. Ropero AB, Alonso-Magdalena P, Ripoll C, Fuentes E, Nadal A. (2006) Rapid endocrine disruption: environmental estrogen actions triggered outside the nucleus. Journal of Steroid Biochemistry and Molecular Biology. 102: 163-169.
  38. Penza M, Montani C, Romani A, Vignolini P, Pampaloni B, Tanini A, Brandi ML, Alonso-Magdalena P, Nadal A, Ottobrini L, Parolini O, Bignotti E, Calza S, Maggi A, Grigolato PG, Di Lorenzo D. (2006) Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner. Endocrinology . 147: 5740-5751.
  39. Quesada I., Todorova M.G., Alonso-Magdalena P., Beltra M., Carneiro E.M., Martin F., Nadal A., Soria B.. (2006) Glucose induces opposite intracellular Ca2+ concentration oscillatory patterns in identified α-and β-cells within intact human islets of Langerhans. Diabetes . 55: 2463-2469.
  40. Bermúdez-Silva, FJ, Serrano A, Díaz-Molina JF, Sánchez-Vera I, Juan-Pico P, Nadal A, Fuentes E, Rodríguez de Fonseca F. (2006) Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. European Journal of Pharmacology. 531: 282-284.
  41. Quesada I, Chin WC, Verdugo P. (2006) Mechanisms of signal transduction in photo-stimulated secretion in Phaeocystis globosa. FEBS Letters . 580: 2201-2206.
  42. Quesada I., Todorova M.G., Soria B.. (2006) Different metabolic responses in α, β, and δ-cells of the islet of Langerhans monitored by redox confocal microscopy. Biophysical Journal . 90: 2641-2650.
  43. Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A. (2006) The estrogenic effect of bisphenol-A disrupts pancreatic β-cell function in vivo and induces insulin resistance. Environmental Health Perspectives . 114: 106-112.
  44. Juan-Pico P, Fuentes E, Bermúdez –Silva F J, Díaz-Molina FJ, Ripoll C , Rodríguez de Fonseca F, Nadal A. (2006) Cannabinoid receptors regulate Ca2+ signals and insulin secretion in pancretic β-cell. Cell Calcium . 39: 155-162.
  45. Quesada I, Verdugo P. (2005) InsP3 signaling induces pulse-modulated Ca2+ signals in the nucleus of airway epithelial ciliated cells. Biophysical Journal . 88: 3946-3953.
  46. Villalobos C, Nadal A, Nunez L, Quesada I, Chamero P, Alonso MT, Garcia-Sancho J. (2005) Bioluminescence imaging of nuclear calcium oscillations in intact pancreatic islets of Langerhans from the mouse. Cell Calcium . 38: 131-9.
  47. Alonso-Magdalena P, Laribi O, Ropero AB , Fuentes E, Ripoll C, Soria B, Nadal A. (2005) Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. Environ Health Perspect. 113: 969-77.
  48. Nadal A, Alonso-Magdalena P, Ripoll C, Fuentes E. (2005) Disentangling the molecular mechanisms of action of endogenous and environmental estrogens. Pflugers Arch. 449: 335-343.
  49. Nadal A, Ropero AB, Fuentes E, Soria B, Ripoll C. (2004) Estrogen and xenoestrogen actions on endocrine pancreas: from ion channel modulation to activation of nuclear function. Steroids . 69: 531-6.
  50. Viso-Leon MC, Ripoll C, Nadal A. (2004) Oestradiol rapidly inhibits Ca2+ signals in ciliary neurons through classical oestrogen receptors in cytoplasm. Pflugers Arch. 449: 33-41.
  51. Quesada I, Soria B. (2004) Intracellular location of KATP channels and sulphonylurea receptors in the pancreatic beta-cell: new targets for oral antidiabetic agents. Curr. Med. Chem. 11: 2707-16.
  52. Chin WC, Orellana MV, Quesada I, Verdugo P. (2004) Secretion in unicellular marine phytoplankton: demonstration of regulated exocytosis in Phaeocystis globosa. Plant Cell Physiol. 45: 535-42.
  53. Soria B, Quesada I, Ropero AB, Pertusa JA, Martin F, Nadal A. (2004) Novel players in pancreatic islet signaling: from membrane receptors to nuclear channels. Diabetes . 53:S86-91.
  54. Quesada I., Martin F., Roche E., Soria B.. (2004) Nutrients induce different Ca2+ signals in cytosol and nucleus in pancreatic β-cells. Diabetes . 53: S92-5.
  55. Bermudez-Silva FJ, León-Quinto T, Martín F, Soria B, Nadal A, Pérez J, Fernández-Llebrez P. (2003) Bovine Subcommissural organ displays spontaneous and synchronous intracellular calcium oscillations. Brain Research . 997: 90-96.
  56. Morales A, Díaz M, Ropero AB, Nadal A, Alonso R. (2003) Estradiol modulates acetylcholine-induced Ca2+ signals in LHRH-releasing GT1-7 cells through a membrane binding site. European Journal of Neuroscience . 18: 2505-2514.
  57. Quesada I, Chin WC, Verdugo P. (2003) ATP-independent lumenal oscillations and release of Ca 2+ and H + from mast cell secretory granules: implications for signal transduction. Biophysical Journal . 85: 963-970.
  58. Quesada I, Fuentes E, Andreu E, Meda P, Nadal A, Soria B. (2003) On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells. American Journal of Physiology. Endocrinology and Metabolism. 284: E980-E987.